Article
Behavioral phenotypes in schizophrenic animal models with multiple combinations of genetic and environmental factors.
Journal of pharmacological sciences - 1 Jan 2013
Hida Hirotake, Mouri Akihiro, Noda Yukihiro
Abstract excerpt
Schizophrenia is a multifactorial psychiatric disorder in which both genetic and environmental factors play a role. Genetic [e.g., Disrupted-in-schizophrenia 1 (DISC1), Neuregulin-1 (NRG1)] and environmental factors (e.g., maternal viral infection, obstetric complications, social stress) may act during the developmental period to increase the incidence of schizophrenia. In animal models, interactions between...
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