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Article

Behavioral phenotypes in schizophrenic animal models with multiple combinations of genetic and environmental factors.

Journal of pharmacological sciences - 1 Jan 2013

Hida Hirotake, Mouri Akihiro, Noda Yukihiro

Abstract excerpt

Schizophrenia is a multifactorial psychiatric disorder in which both genetic and environmental factors play a role. Genetic [e.g., Disrupted-in-schizophrenia 1 (DISC1), Neuregulin-1 (NRG1)] and environmental factors (e.g., maternal viral infection, obstetric complications, social stress) may act during the developmental period to increase the incidence of schizophrenia. In animal models, interactions between...

Topics

Adenylyl Cyclases
Animals
Behavior, Animal
Disease Models, Animal
Gene-Environment Interaction
Humans
Mice
Nerve Tissue Proteins
Neuregulin-1
Nuclear Receptor Subfamily 4, Group A, Member 2
Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phencyclidine

Phenotype

Point Mutation

Schizophrenia

Schizophrenic Psychology

Source

Identifiers

PMID: 23449491
DOI: 10.1254/jphs.12r15cp

Genes

DISC1
NRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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