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Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis.

Human molecular genetics - 15 Feb 2013

Lee S Hong, Harold Denise, Nyholt Dale R, Goddard Michael E, Zondervan Krina T, Williams Julie, Montgomery Grant W, Wray Naomi R, Visscher Peter M

Abstract excerpt

Common diseases such as endometriosis (ED), Alzheimer's disease (AD) and multiple sclerosis (MS) account for a significant proportion of the health care burden in many countries. Genome-wide association studies (GWASs) for these diseases have identified a number of individual genetic variants contributing to the risk of those diseases. However, the effect size for most variants is small and collectively the known...

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PMID: 23193196
DOI: 10.1093/hmg/dds491
PMCID: PMC3554206

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