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High ubiquitin‐specific protease 44 expression induces DNA aneuploidy and provides independent prognostic information in gastric cancer

23 May 2017

Abstract excerpt

Chromosomal instability (CIN), characterized by aneuploidy, is a major molecular subtype of gastric cancer. The deubiquitinase USP44 is an important regulator of APC activation in the spindle checkpoint and leads to proper chromosome separation to prevent aneuploidy. Aberrant expression of USP44 leads CIN in cells; however, the correlation between USP44 and DNA aneuploidy in gastric cancer is largely unknown. We...

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PMID: 28544703
DOI: 10.1002/cam4.1090

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