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Article

A genetic variant in the promoter region of miR-34b/c is associated with a reduced risk of colorectal cancer.

Biological chemistry - 1 Mar 2013

Gao Lin-Bo, Li Li-Juan, Pan Xin-Min, Li Zhao-Hui, Liang Wei-Bo, Bai Peng, Zhu Yin-Hua, Zhang Lin

Abstract excerpt

The miR-34 family members, described as potential tumor suppressors, were downregulated in colorectal cancer (CRC). Loss of miR-34 impairs TP53-mediated cell death, while overexpression of miR-34 induces apoptosis. A potentially functional polymorphism (i.e., rs4938723T/C) in the promoter region of pri-miR-34b/c was predicted to influence the GATA-X binding sites. We aimed to investigate the association between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23183747
DOI: 10.1515/hsz-2012-0297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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