Polymorphisms of the pri-miR-34b/c promoter and TP53 codon 72 are associated with risk of colorectal cancer.

doi:10.3892/or.2013.2926

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Article

Polymorphisms of the pri-miR-34b/c promoter and TP53 codon 72 are associated with risk of colorectal cancer.

Oncology reports - 1 Feb 2014

Oh Jisu, Kim Jong Woo, Lee Bo Eun, Jang Moon Ju, Chong So Young, Park Pil Won, Hwang Seong Gyu, Oh Doyeun, Kim Nam Keun

Abstract excerpt

The microRNA (miR)-34 family is a direct transcriptional target of tumor-suppressor TP53 and loss of miR-34 function may impair TP53-mediated cell cycle arrest and apoptosis. In the present study, we investigated whether the single nucleotide polymorphisms (SNPs) rs4938723 (T>C) in the promoter region of miR-34b/c and Arg72Pro (G>C) in codon 72 of TP53 are independently or complementarily associated with the...

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PMID: 24337371
DOI: 10.3892/or.2013.2926

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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