Article
A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocellular carcinoma.
International journal of cancer - 15 Jan 2011
Xu Yan, Liu Li, Liu Jibin, Zhang Yixin, Zhu Jian, Chen Jianguo, Liu Sheng, Liu Zheng, Shi Haibin, Shen Hongbing, Hu Zhibin
Abstract excerpt
The miR-34 family members are direct transcriptional targets of tumor suppressor p53, and loss of miR-34 function can impair p53-mediated cell cycle arrest and apoptosis. A potentially functional SNP rs4938723 (T > C) was found in the promoter region of pri-miR-34b/c (423 bp from the transcription start site), located in the CpG island and might affect transcription factor GATA binding and therefore pri-miR-34b/c...
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