Efficient tumorigenesis by mutation-induced failure to terminate microRNA-mediated adaptive hyperplasia.

Abstract excerpt

Seven current contending cancer theories consider different sets of critical events as sufficient for tumorigenesis. These theories, most recently the microRNA dysregulation (MRD) theory, have overlapping attributes and extensive empirical support, but also some discrepancies, and some do not address both benign and malignant tumorigenesis. By definition, the most efficient tumorigenic pathways will dominate...

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