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The tumor suppression theory of aging

11 Oct 2021

Abstract excerpt

Despite continued increases in human life expectancy, the factors determining the rate of human biological aging remain unknown. Without understanding the molecular mechanisms underlying aging, efforts to prevent aging are unlikely to succeed. The tumor suppression theory of aging introduced here proposes somatic mutation as the proximal cause of aging, but postulates that oncogenic transformation and clonal...

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PMID: 34637937
DOI: 10.1016/j.mad.2021.111583

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