Article
[Non-classical cellular and molecular deficits in cancer development].
Gaceta medica de Mexico - 1 Jan 2000
Valdespino-Gómez Víctor Manuel, Valdespino-Castillo Víctor Edmundo
Abstract excerpt
A wide number of genetic and epigenetic changes are required to drive normal cells towards malignancy. These changes participate in oncogenic intracellular pathways that allow tumor cells proliferation and dissemination. Hanahan and Weinberg' in their seminal paper "The hallmarks of cancer" described the classic cell hallmarks acquired in cancer development and progression: self-sufficiency in growth signals,...
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