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Article

Exonal elements and factors involved in the depolarization-induced alternative splicing of neurexin 2.

Journal of molecular neuroscience : MN - 1 May 2013

Rozic G, Lupowitz Z, Zisapel N

Abstract excerpt

The neurexin genes (NRXN1, NRXN2, and NRXN3) encode polymorphic presynaptic proteins that are implicated in synaptic plasticity and memory processing. In rat brain neurons grown in culture, depolarization induces reversible, calcium-dependent, repression of NRXN2α exon 11 (E11) splicing. Using Neuro2a cells as a model, we explored E11 cis elements and trans-acting factors involved in alternative splicing of...

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Share to Alternative Splicing
Share to Cell Line, Tumor
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Potentials

Share to Nerve Tissue Proteins

Share to Nucleotide Motifs

Share to Regulatory Sequences, Ribonucleic Acid

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 23180095
DOI: 10.1007/s12031-012-9919-x
PMCID: PMC3622022

Genes

NRXN1
NRXN2
NRXN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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