Transcriptional profiling of depolarization-dependent phenotypic alterations in primary cultures of developing granule neurons.

doi:10.1016/j.brainres.2006.08.043

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Article

Transcriptional profiling of depolarization-dependent phenotypic alterations in primary cultures of developing granule neurons.

Brain research - 13 Nov 2006

Bui Cuong J, McGann Alexandra C, Middleton Frank A, Beaman-Hall Carol M, Vallano Mary Lou

Abstract excerpt

Rat cerebellar granule neurons cultured in medium supplemented with elevated KCl are extensively used as a model to examine the coupling between neural activity and Ca(2+)-dependent gene expression. Elevated (25 mM) KCl is believed to mimic endogenous neural activity because it promotes depolarization and Ca(+2)-dependent survival and some aspects of maturation. By comparison, at least half of the granule neurons...

Topics

Animals
Animals, Newborn
Calcineurin
Calcineurin Inhibitors
Calcium
Calcium Signaling
Cell Differentiation
Cell Membrane
Cell Survival
Cells, Cultured
Cerebellar Cortex
DNA Fingerprinting
Excitatory Amino Acid Agonists

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation

Membrane Potentials

N-Methylaspartate

Neurons

Phenotype

Source

Open in PubMed

Identifiers

PMID: 16989786
DOI: 10.1016/j.brainres.2006.08.043

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