Article
A CaMK IV responsive RNA element mediates depolarization-induced alternative splicing of ion channels.
Nature - 19 Apr 2001
Xie J, Black D L
Abstract excerpt
Calcium regulation of gene expression is critical for the long-lasting activity-dependent changes in cellular electrical properties that underlie important physiological functions such as learning and memory. Cellular electrical properties are diversified through the extensive alternative splicing of ion channel pre-messenger RNAs; however, the regulation of splicing by cell signalling pathways has not been well...
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