Article
Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca(2+) //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survival.
The Journal of biological chemistry - 17 Oct 2003
Linseman Daniel A, Bartley Christopher M, Le Shoshona S, Laessig Tracey A, Bouchard Ron J, Meintzer Mary Kay, Li Mingtao, Heidenreich Kim A
Abstract excerpt
Cerebellar granule neuron (CGN) survival depends on activity of the myocyte enhancer factor-2 (MEF2) transcription factors. Neuronal MEF2 activity is regulated by depolarization via a mechanism that is presently unclear. Here, we show that depolarization-mediated MEF2 activity and CGN survival are compromised by overexpression of the MEF2 repressor histone deacetylase-5 (HDAC5). Furthermore, removal of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.