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Article

CREB-dependent Nur77 induction following depolarization in PC12 cells and neurons is modulated by MEF2 transcription factors.

Journal of neurochemistry - 1 Feb 2010

Lam Brian Yee Hong, Zhang Wenting, Ng David Chi-Heng, Maruthappu Mahiben, Roderick Hywel Llewelyn, Chawla Sangeeta

Abstract excerpt

Expression of the nuclear orphan receptor gene Nur77 in neuronal cells is induced by activity-dependent increases in intracellular Ca2+ ions. Ca2+ responsiveness of the Nur77 gene has been attributed to two distinct DNA regulatory regions that recruit the transcription factors cAMP response element binding protein (CREB) and myocyte enhancer factor-2 (MEF2). Here we used dominant interfering and constitutively...

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PMID: 19968756
DOI: 10.1111/j.1471-4159.2009.06521.x

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