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Article

β-Subunit of the voltage-gated Ca2+ channel Cav1.2 drives signaling to the nucleus via H-Ras.

Proceedings of the National Academy of Sciences of the United States of America - 11 Sept 2018

Servili Evrim, Trus Michael, Maayan Daphne, Atlas Daphne

Abstract excerpt

Depolarization-induced signaling to the nucleus by the L-type voltage-gated calcium channel Cav1.2 is widely assumed to proceed by elevating intracellular calcium. The apparent lack of quantitative correlation between Ca2+ influx and gene activation suggests an alternative activation pathway. Here, we demonstrate that membrane depolarization of HEK293 cells transfected with α11.2/β2b/α2δ subunits (Cav1.2)...

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Identifiers

PMID: 30150369
DOI: 10.1073/pnas.1805380115
PMCID: PMC6140482

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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