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Article

Notch signaling during development requires the function of awd, the Drosophila homolog of human metastasis suppressor gene Nm23.

BMC biology - 14 Feb 2014

Ignesti Marilena, Barraco Marilena, Nallamothu Gouthami, Woolworth Julie A, Duchi Serena, Gargiulo Giuseppe, Cavaliere Valeria, Hsu Tien

Abstract excerpt

BACKGROUND: The Drosophila abnormal wing discs (awd) belongs to a highly conserved family of genes implicated in metastasis suppression, metabolic homeostasis and epithelial morphogenesis. The cellular function of the mammalian members of this family, the Nm23 proteins, has not yet been clearly defined. Previous awd genetic analyses unraveled its endocytic role that is required for proper internalization of...

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Identifiers

PMID: 24528630
DOI: 10.1186/1741-7007-12-12
PMCID: PMC3937027

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