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Article

Mutations in the estrogen receptor ligand binding domain discriminate between hormone-dependent transactivation and transrepression.

The Journal of biological chemistry - 18 Aug 2000

Valentine J E, Kalkhoven E, White R, Hoare S, Parker M G

Abstract excerpt

The estrogen receptor (ER) suppresses transcriptional activity of the RelA subunit of nuclear factor-kappaB in a hormone-dependent manner by a mechanism involving both the receptor DNA binding domain and ligand binding domain (LBD). In this study we examine the role of the ER LBD in mediating ligand-dependent RelA transrepression. Both ERalpha and ERbeta inhibit RelA in response to 17beta-estradiol but not in the...

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Identifiers

PMID: 10840033
DOI: 10.1074/jbc.M002497200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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