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Article

The F-domain of estrogen receptor-alpha inhibits ligand induced receptor dimerization.

Molecular and cellular endocrinology - 25 Nov 2008

Yang Jun, Singleton David W, Shaughnessy Elizabeth A, Khan Sohaib A

Abstract excerpt

The role of the carboxyl terminal F-domain of estrogen receptor (ERalpha) is uncertain, but evidence suggests that this region may impart internal restraint on ER dimerization in the presence of 17beta-estradiol (E2). To identify the C-terminal residues affecting human ERalpha activation, we created a series of deletions and examined E2 induced receptor dimerization and transactivation. Deletion of the final 24...

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Identifiers

PMID: 18762230
DOI: 10.1016/j.mce.2008.08.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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