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Article

Molecular determinants of the estrogen receptor-coactivator interface.

Molecular and cellular biology - 1 May 1999

Mak H Y, Hoare S, Henttu P M, Parker M G

Abstract excerpt

Transcriptional activation by the estrogen receptor is mediated through its interaction with coactivator proteins upon ligand binding. By systematic mutagenesis, we have identified a group of conserved hydrophobic residues in the ligand binding domain that are required for binding the p160 family of coactivators. Together with helix 12 and lysine 366 at the C-terminal end of helix 3, they form a hydrophobic...

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Identifiers

PMID: 10207113
DOI: 10.1128/MCB.19.5.3895
PMCID: PMC84247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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