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Article

APLF promotes the assembly and activity of non-homologous end joining protein complexes.

The EMBO journal - 9 Jan 2013

Grundy Gabrielle J, Rulten Stuart L, Zeng Zhihong, Arribas-Bosacoma Raquel, Iles Natasha, Manley Katie, Oliver Antony, Caldecott Keith W

Abstract excerpt

Non-homologous end joining (NHEJ) is critical for the maintenance of genetic integrity and DNA double-strand break (DSB) repair. NHEJ is regulated by a series of interactions between core components of the pathway, including Ku heterodimer, XLF/Cernunnos, and XRCC4/DNA Ligase 4 (Lig4). However, the mechanisms by which these proteins assemble into functional protein-DNA complexes are not fully understood. Here, we...

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Topics

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Share to DNA Ligases
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA-(Apurinic or Apyrimidinic Site) Lyase

Share to DNA Breaks, Double-Stranded

Share to DNA End-Joining Repair

Share to DNA Ligase ATP

Share to Ku Autoantigen

Share to Poly-ADP-Ribose Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23178593
DOI: 10.1038/emboj.2012.304
PMCID: PMC3545299

Genes

APLF
XRCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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APLF promotes the assembly and activity of non-homologous end joining protein complexes.PMID 23178593Read ↗

Non‐homologous end joining: Common interaction sites and exchange of multiple factors in the DNA repair processSemantic proximity Read ↗

Evolutionary and functional conservation of the DNA non-homologous end-joining protein, XLF/Cernunnos.Semantic proximity Read ↗

XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining.Semantic proximity Read ↗

Homeodomain protein PRRX1 anchors the Ku heterodimers at DNA double-strand breaks to promote nonhomologous end-joining.Semantic proximity Read ↗

The spatial organization of non-homologous end joining: From bridging to end joiningSemantic proximity Read ↗

Investigating the regulation of DNA non-homologous end-joining through Ku70/80 interacting factorsSemantic proximity Read ↗

Functional significance of the interaction with Ku in DNA double-strand break recognition of XLF.Semantic proximity Read ↗

Deficiency of XLF and PAXX prevents DNA double-strand break repair by non-homologous end joining in lymphocytesSemantic proximity Read ↗

Zinc finger protein ZNF384 is an adaptor of Ku to DNA during classical non-homologous end-joiningSemantic proximity Read ↗

PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repairSemantic proximity Read ↗

Cooperative assembly of a protein-DNA filament for nonhomologous end joining.Semantic proximity Read ↗

Repair of double-strand breaks by end joining.Semantic proximity Read ↗

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