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Article

Functional significance of the interaction with Ku in DNA double-strand break recognition of XLF.

FEBS letters - 23 Mar 2011

Yano Ken-ichi, Morotomi-Yano Keiko, Lee Kyung-Jong, Chen David J

Abstract excerpt

Ku heterodimer is essential for the repair of DNA double-strand breaks (DSBs) by non-homologous end-joining (NHEJ). Ku recruits XLF, also known as Cernunnos, to DSBs. Here we report domain analyses of Ku-XLF interaction. The heterodimeric domain of Ku was found to be sufficient for the recruitment of XLF to DSBs and for the interaction of Ku with XLF. A small C-terminal deletion of XLF completely abolished...

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Topics

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Share to Antigens, Nuclear
Share to DNA Breaks, Double-Stranded
Share to DNA Repair Enzymes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Microscopy, Fluorescence

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Source

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Identifiers

PMID: 21349273
DOI: 10.1016/j.febslet.2011.02.020
PMCID: PMC3066473

Genes

XRCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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