Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cooperative assembly of a protein-DNA filament for nonhomologous end joining.

The Journal of biological chemistry - 21 Jun 2013

Tsai Chun J, Chu Gilbert

Abstract excerpt

Nonhomologous end joining repairs DNA double-strand breaks created by ionizing radiation and V(D)J recombination. Ku, XRCC4/Ligase IV (XL), and XLF have a remarkable mismatched end (MEnd) ligase activity, particularly for ends with mismatched 3' overhangs, but the mechanism has remained obscure....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Nuclear
Share to DNA End-Joining Repair
Share to DNA Ligase ATP

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Ligases

Share to DNA Repair Enzymes

Share to Electrophoresis, Polyacrylamide Gel

Share to Electrophoretic Mobility Shift Assay

Share to Ku Autoantigen

Source

Open in PubMed Open full text

Identifiers

PMID: 23620595
DOI: 10.1074/jbc.M113.464115
PMCID: PMC3689955

Genes

XRCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23620595-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cooperative assembly of a protein-DNA filament for nonhomologous end joining.PMID 23620595Read ↗

The spatial organization of non-homologous end joining: From bridging to end joiningSemantic proximity Read ↗

XRCC4's interaction with XLF is required for coding (but not signal) end joining.Semantic proximity Read ↗

Non‐homologous end joining: Common interaction sites and exchange of multiple factors in the DNA repair processSemantic proximity Read ↗

Structural and Functional Interaction between the Human DNA Repair Proteins DNA Ligase IV and XRCC4Semantic proximity Read ↗

Crystal structure of human XLF: a twist in nonhomologous DNA end-joining.Semantic proximity Read ↗

Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining.Semantic proximity Read ↗

APLF promotes the assembly and activity of non-homologous end joining protein complexes.Semantic proximity Read ↗

Functional significance of the interaction with Ku in DNA double-strand break recognition of XLF.Semantic proximity Read ↗

Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance.Semantic proximity Read ↗

PAXX binding to the NHEJ machinery explains functional redundancy with XLFSemantic proximity Read ↗

Non-homologous end joining minimizes errors by coordinating DNA processing with ligationSemantic proximity Read ↗

LIG1 syndrome mutations remodel a cooperative network of ligand binding interactions to compromise ligation efficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.