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Article

Cooperative assembly of a protein-DNA filament for nonhomologous end joining.

The Journal of biological chemistry - 21 Jun 2013

Tsai Chun J, Chu Gilbert

Abstract excerpt

Nonhomologous end joining repairs DNA double-strand breaks created by ionizing radiation and V(D)J recombination. Ku, XRCC4/Ligase IV (XL), and XLF have a remarkable mismatched end (MEnd) ligase activity, particularly for ends with mismatched 3' overhangs, but the mechanism has remained obscure. Here, we showed XL required Ku to bind DNA, whereas XLF required both Ku and XL to bind DNA. We detected cooperative...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Electrophoresis, Polyacrylamide Gel

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Source

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Identifiers

PMID: 23620595
DOI: 10.1074/jbc.M113.464115
PMCID: PMC3689955

Genes

XRCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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