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Zinc finger protein ZNF384 is an adaptor of Ku to DNA during classical non-homologous end-joining

12 Nov 2021

Abstract excerpt

DNA double-strand breaks (DSBs) are among the most deleterious types of DNA damage as they can lead to mutations and chromosomal rearrangements, which underlie cancer development. Classical non-homologous end-joining (cNHEJ) is the dominant pathway for DSB repair in human cells, involving the DNA-binding proteins XRCC6 (Ku70) and XRCC5 (Ku80). Other DNA-binding proteins such as Zinc Finger (ZnF) domain-containing...

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PMID: 34772923
DOI: 10.1038/s41467-021-26691-0

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