Article
Isolation of temperature-sensitive CHO-K1 cell mutants exhibiting chromosomal instability and reduced DNA synthesis at nonpermissive temperature.
Somatic cell and molecular genetics - 1 Sept 1990
Tsuji H, Matsudo Y, Tsuji S, Hanaoka F, Hyodo M, Hori T
Abstract excerpt
Twenty-five temperature-sensitive (ts) mutants were isolated from Chinese hamster CHO-K1 cells after mutagenization with N-methyl-N'-nitro-N-nitrosoguanidine. Of 13 complementation groups identified, nine exhibited chromosomal instability at a nonpermissive temperature. They were classified into...
Topics
- Animals
- Cell Division
- Cell Line
- Cell Survival
- Chromosome Aberrations
- Cricetinae
- Cricetulus
- DNA Replication
- Female
- Genetic Complementation Test
- Mutation
- Ovary
- Sister Chromatid Exchange
- Temperature