Identification of cellular defect in UVS1, a UV-sensitive Chinese hamster ovary mutant cell line.

Article

Identification of cellular defect in UVS1, a UV-sensitive Chinese hamster ovary mutant cell line.

Cancer research - 1 Feb 1993

Numata M, Hata H, Shiomi T, Matsunaga T, Mori T, Nikaido O, Yasui A, Oikawa A

Abstract excerpt

UVS1 is an intermediately UV-sensitive Chinese hamster ovary mutant originally isolated by its hypersensitivity to an anticancer drug, 1-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-3-(2-chloroethyl)-3-nitrosour ea hydrochloride. By cell fusion analysis, UVS1 complemented the UV sensitivity of the mo...

Topics

Animals
CHO Cells
Cell Line
Cricetinae
DNA
DNA Damage
DNA Repair
DNA, Neoplasm
Genome
Kinetics
Lymphoma
Mice
Mutation
Nimustine
Sensitivity and Specificity
Tumor Cells, Cultured
Ultraviolet Rays

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