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Article

Differential effect of gestation stage on benzo(a)pyrene-induced micronucleus formation and/or covalent DNA modifications in mice.

Cancer research - 1 Apr 1990

Wang M Y, Lu L J

Abstract excerpt

Benzo(a)pyrene (BP), an environmental carcinogen, binds ubiquitously to the DNA of maternal and fetal tissues (Lu et al., Cancer Res., 46: 3046-3054, 1986). These studies further investigated the effect of gestation age on the induction of genetic damage by BP. Timed-pregnant ICR mice were treated with one dose of BP on various days of gestation and sacrificed 24-120 h after treatment. At the molecular level, BP...

Topics

Age Factors
Animals
Benzo(a)pyrene
DNA
DNA Damage
Dose-Response Relationship, Drug
Embryo, Mammalian
Female
Gestational Age
Mice
Mice, Inbred ICR
Micronucleus Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Pregnancy

Source

Identifiers

PMID: 2317806

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2317806-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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