Benzo(a)pyrene causes PRKAA1/2‐dependent ID2 loss in trophoblast stem cells

doi:10.1002/mrd.21178

Article

Benzo(a)pyrene causes PRKAA1/2‐dependent ID2 loss in trophoblast stem cells

30 Mar 2010

Abstract excerpt

Benzo(a)pyrene (BaP), a cigarette smoke component, is metabolized to diol esters (BPDE) that bind to DNA and form mutagenic BPDE-DNA adducts. BaP activates stress enzymes including stress-activated protein kinase/jun kinase (MAPK8/9) in embryos, AMP-activated protein kinase alpha1/2 subunits (PRKAA1/2) in somatic cells, and inhibits the proliferation of trophoblast cell lineages. The loss of transcription factor...

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.