Article
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter.
Nature - 17 Feb 2000
Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt S J, Moynihan J, Paw B H, Drejer A, Barut B, Zapata A, Law T C, Brugnara C, Lux S E, Pinkus G S, Pinkus J L, Kingsley P D, Palis J, Fleming M D, Andrews N C, Zon L I
Abstract excerpt
Defects in iron absorption and utilization lead to iron deficiency and overload disorders. Adult mammals absorb iron through the duodenum, whereas embryos obtain iron through placental transport. Iron uptake from the intestinal lumen through the apical surface of polarized duodenal enterocytes is mediated by the divalent metal transporter, DMTi. A second transporter has been postulated to export iron across the...
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