Article
Mutation of Drosophila focal adhesion kinase induces bang-sensitive behavior and disrupts glial function, axonal conduction and synaptic transmission.
The European journal of neuroscience - 1 Jun 2008
Ueda Atsushi, Grabbe Caroline, Lee Jihye, Lee Jisue, Palmer Ruth H, Wu Chun-Fang
Abstract excerpt
The role of the conserved focal adhesion kinase (FAK) family of protein tyrosine kinases in the development and physiological functions of the CNS has long been an area of interest among neuroscientists. In this report, we observe that Drosophila mutants lacking Fak56 exhibit a decreased lifespan, accompanied by a bang-sensitive phenotype, which is characterized by sensitivity to mechanical and high-frequency...
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