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Article

Developmental loss of neurofibromin across distributed neuronal circuits drives excessive grooming in Drosophila.

PLoS genetics - 1 Jul 2020

King Lanikea B, Boto Tamara, Botero Valentina, Aviles Ari M, Jomsky Breanna M, Joseph Chevara, Walker James A, Tomchik Seth M

Abstract excerpt

Neurofibromatosis type 1 is a monogenetic disorder that predisposes individuals to tumor formation and cognitive and behavioral symptoms. The neuronal circuitry and developmental events underlying these neurological symptoms are unknown. To better understand how mutations of the underlying gene (NF1) drive behavioral alterations, we have examined grooming in the Drosophila neurofibromatosis 1 model. Mutations of...

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Identifiers

PMID: 32697780
DOI: 10.1371/journal.pgen.1008920
PMCID: PMC7398555

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