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Article

Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels.

Proceedings of the National Academy of Sciences of the United States of America - 20 Aug 1996

Ragsdale D S, McPhee J C, Scheuer T, Catterall W A

Abstract excerpt

Voltage-gated Na+ channels are the molecular targets of local anesthetics, class I antiarrhythmic drugs, and some anticonvulsants. These chemically diverse drugs inhibit Na+ channels with complex voltage- and frequency-dependent properties that reflect preferential drug binding to open and inacti...

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Identifiers

PMID: 8799190
DOI: 10.1073/pnas.93.17.9270
PMCID: PMC38631

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-8799190-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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