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A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation

12 Nov 2018

Abstract excerpt

Antiretroviral therapy (ART) suppresses viral replication in people living with HIV. Yet, infected cells persist for decades on ART and viremia returns if ART is stopped. Persistence has been attributed to viral replication in an ART sanctuary and long-lived and/or proliferating latently infected cells. Using ecological methods and existing data, we infer that >99% of infected cells are members of clonal...

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PMID: 30446650
DOI: 10.1038/s41467-018-06843-5

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