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Article

Genetic polymorphisms of methylenetetrahydrofolate reductase and promoter methylation of MGMT and FHIT genes in diffuse large B cell lymphoma risk in Middle East.

Annals of hematology - 1 Dec 2007

Siraj Abdul K, Ibrahim Muna, Al-Rasheed Maha, Bu Rong, Bavi Prashant, Jehan Zeenath, Abubaker Jehad, Murad Walid, Al-Dayel Fouad, Ezzat Adnan, El-Solh Hassan, Uddin Shahab, Al-Kuraya Khawla

Abstract excerpt

Diffuse large B cell lymphoma (DLBCL) is one of the most common non-Hodgkin's lymphoma types. Methylenetetrahydrofolate reductase (MTHFR) balances the pool of folate coenzymes in one carbon metabolism of deoxyribonucleic acid (DNA) synthesis and methylation; both are implicated in carcinogenesis of many types of cancer including lymphoma. Two common variants in the MTHFR gene (C677T and A1298C) have been...

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Share to Acid Anhydride Hydrolases
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Repair Enzymes

Share to Lymphoma, Large B-Cell, Diffuse

Share to Methylenetetrahydrofolate Reductase (NADPH2)

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Identifiers

PMID: 17712558
DOI: 10.1007/s00277-007-0350-2

Genes

MTHFR
FHIT
MGMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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