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Article

PXR and CAR single nucleotide polymorphisms influence plasma efavirenz levels in South African HIV/AIDS patients.

BMC medical genetics - 22 Nov 2012

Swart Marelize, Whitehorn Heather, Ren Yuan, Smith Peter, Ramesar Rajkumar S, Dandara Collet

Abstract excerpt

BACKGROUND: This study investigated variation in NR1I2 and NR1I3 and its effect on plasma efavirenz levels in HIV/AIDS patients. Variability in plasma drug levels has largely led research on identifying causative variants in drug metabolising enzyme (DME) genes, with little focus on the nuclear receptor genes NR1I2 and NR1I3, coding for PXR and CAR, respectively, that are involved in regulating DMEs. METHODS: 464...

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Identifiers

PMID: 23173844
DOI: 10.1186/1471-2350-13-112
PMCID: PMC3523080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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