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Article

Constitutive androstane receptor and pregnane X receptor genotype influence efavirenz plasma concentration and CYP2B6 enzyme activity.

Scientific reports - 11 Jun 2022

Petros Zelalem, Habtewold Abiy, Makonnen Eyasu, Aklillu Eleni

Abstract excerpt

Efavirenz is metabolized by CYP2B6, an inducible enzyme whose expression is regulated by the constitutive androstane receptor and pregnane X receptor nuclear receptors. CAR and PXR are encoded by genetically polymorphic NR1I2 and NR1I3, respectively. We examined the impact of NR1I2 and NR1I3 genotype on plasma EFV concentration and CYP2B6 enzyme activity among TB-HIV co-infected patients in Ethiopia....

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Identifiers

PMID: 35690682
DOI: 10.1038/s41598-022-14032-0
PMCID: PMC9188543

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