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Article

A metabolic signature of long life in Caenorhabditis elegans.

BMC biology - 10 Feb 2010

Fuchs Silke, Bundy Jacob G, Davies Sarah K, Viney Jonathan M, Swire Jonathan S, Leroi Armand M

Abstract excerpt

BACKGROUND: Many Caenorhabditis elegans mutations increase longevity and much evidence suggests that they do so at least partly via changes in metabolism. However, up until now there has been no systematic investigation of how the metabolic networks of long-lived mutants differ from those of normal worms. Metabolomic technologies, that permit the analysis of many untargeted metabolites in parallel, now make this...

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Identifiers

PMID: 20146810
DOI: 10.1186/1741-7007-8-14
PMCID: PMC2829508

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