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Article

Hypoxia‐inducible factor‐1 as a therapeutic target in cancer

22 Nov 2012

Abstract excerpt

Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that immortalizes tumors by inducing key genes in cancer biology, including angiogenesis, glycolysis, invasion, and metastasis. Overexpression of HIF-1α is thus associated with resistance to cancer chemotherapy and increased patient mortality in several cancer phenotypes. In the present review, we summarize the role of intratumoral hypoxia and bioactive...

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PMID: 23173651
DOI: 10.1111/jgh.12038

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