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Article

HIF-1 Signaling in Drug Resistance to Chemotherapy

13 Apr 2014

Abstract excerpt

Activation of hypoxia-inducible factor 1 (HIF-1) signaling is observed in a broad range of human cancers due to tumor hypoxia and epigenetic mechanisms. HIF-1 activation leads to the transcription of a plethora of target genes that promote physiological changes associated with therapeutic resistance, including the inhibition of apoptosis and senescence and the activation of drug efflux and cellular metabolism. As...

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PMID: 24735366
DOI: 10.2174/0929867321666140414101056

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