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Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunity

1 Feb 2024

Abstract excerpt

Cancer remains one of the most formidable challenges in modern medicine, due to its complex and dynamic nature, which demands innovative therapeutic approaches. One major challenge to cancer treatment is the tumour microenvironment and in particular tumour hypoxia (low oxygen levels), which contributes to tumour progression and immune evasion. At the cellular level, this is primarily governed by hypoxia-inducible...

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PMID: 39886164
DOI: 10.1136/bmjonc-2023-000154

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