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Ketone body utilization drives tumor growth and metastasis

22 Oct 2012

Abstract excerpt

We have previously proposed that catabolic fibroblasts generate mitochondrial fuels (such as ketone bodies) to promote the anabolic growth of human cancer cells and their metastasic dissemination. We have termed this new paradigm "two-compartment tumor metabolism." Here, we further tested this hypothesis by using a genetic approach. For this purpose, we generated hTERT-immortalized fibroblasts overexpressing the...

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PMID: 23082722
DOI: 10.4161/cc.22137

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