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Article

Strong induction of <scp>AIM</scp>2 expression in human epidermis in acute and chronic inflammatory skin conditions

28 Sept 2012

Abstract excerpt

Absent in melanoma 2 (AIM2) is a double-stranded DNA receptor, and its activation initiates an interleukin-1 beta processing inflammasome. AIM2 is implicated in host defense against several pathogens, but could hypothetically also contribute to autoinflammatory or autoimmune diseases, such as is the case for NLRP3. Using thoroughly characterised antibodies, we analysed AIM2 expression in human tissues and primary...

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PMID: 23171461
DOI: 10.1111/exd.12037

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