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Article

Human keratinocytes express AIM2 and respond to dsDNA with IL-1β secretion

10 Oct 2011

Abstract excerpt

Keratinocytes have been recognized to actively participate in the skin immune response. It has been shown that keratinocytes express all components that are necessary to form the NLRP3 inflammasome complex including the adapter protein ASC and caspase-1. In this study, we investigated the presence and activity of the recently identified absent in melanoma 2 (AIM2) inflammasome in human keratinocytes. We were able...

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PMID: 22092578
DOI: 10.1111/j.1600-0625.2011.01382.x

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