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Article

Clinical drug resistance linked to interconvertible phenotypic and functional states of tumor-propagating cells in multiple myeloma.

Blood - 10 Jan 2013

Chaidos Aristeidis, Barnes Chris P, Cowan Gillian, May Philippa C, Melo Valeria, Hatjiharissi Evdoxia, Papaioannou Maria, Harrington Heather, Doolittle Helen, Terpos Evangelos, Dimopoulos Meletios, Abdalla Saad, Yarranton Helen, Naresh Kikkeri, Foroni Letizia, Reid Alistair, Rahemtulla Amin, Stumpf Michael, Roberts Irene, Karadimitris Anastasios

Abstract excerpt

The phenotype and function of cells enriched in tumor-propagating activity and their relationship to the phenotypic architecture in multiple myeloma (MM) are controversial. Here, in a cohort of 30 patients, we show that MM composes 4 hierarchically organized, clonally related subpopulations, which, although phenotypically distinct, share the same oncogenic chromosomal abnormalities as well as immunoglobulin heavy...

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Share to Cell Separation
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunophenotyping

Share to In Situ Hybridization, Fluorescence

Share to Models, Theoretical

Share to Multiple Myeloma

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Share to Transplantation, Heterologous

Source

Identifiers

PMID: 23169779
DOI: 10.1182/blood-2012-06-436220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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