Article
[Correlation of cholesterol 24-hydroxylase and ATP-binding cassette transporter A1 polymorphisms with Alzheimer's disease].
Zhonghua yi xue za zhi - 6 Mar 2007
Wang Fen, Jia Jian-Ping
Abstract excerpt
OBJECTIVE: To investigate the association of the single nucleotide polymorphisms (SNPs) A-->G in the intron 2 of cholesterol 24-hydroxylase (CYP46) gene and G-->A (R219K) in the exon 6 of ATP-binding cassette transporter A1 (ABCA1) gene with sporadic Alzheimer's disease (SAD) in the Han Chinese population. METHODS: Peripheral blood samples were collected from 168 SAD patients, 74 males and 94 females, aged 74 +/-...
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