Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin.

doi:10.1016/0092-8674(95)90369-0

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Article

Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin.

Cell - 7 Apr 1995

Witke W, Sharpe A H, Hartwig J H, Azuma T, Stossel T P, Kwiatkowski D J

Abstract excerpt

Gelsolin, an 82 kDa actin-binding protein, has potent actin filament-severing activity in vitro. To investigate the in vivo function of gelsolin, transgenic gelsolin-null (Gsn-) mice were generated and found to have normal embryonic development and longevity. However, platelet shape changes are d...

Topics

Actins
Animals
Blood Platelets
Cell Movement
Cells, Cultured
Fetus
Fibroblasts
Gelsolin
Gene Expression Regulation, Developmental
Hemostasis
Inflammation
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Transgenic
Mutation
Neutrophils
RNA, Messenger

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