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Article

Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin.

Cell - 7 Apr 1995

Witke W, Sharpe A H, Hartwig J H, Azuma T, Stossel T P, Kwiatkowski D J

Abstract excerpt

Gelsolin, an 82 kDa actin-binding protein, has potent actin filament-severing activity in vitro. To investigate the in vivo function of gelsolin, transgenic gelsolin-null (Gsn-) mice were generated and found to have normal embryonic development and longevity. However, platelet shape changes are decreased in Gsn- mice, causing prolonged bleeding times. Neutrophil migration in vivo into peritoneal exudates and in...

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Identifiers

PMID: 7720072
DOI: 10.1016/0092-8674(95)90369-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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