Article
Development of a temperature-switch PCR-based SNP typing method for Mycobacterium ulcerans.
PLoS neglected tropical diseases - 1 Jan 2012
Röltgen Katharina, Assan-Ampah Kobina, Danso Emelia, Yeboah-Manu Dorothy, Pluschke Gerd
Abstract excerpt
Mycobacterium ulcerans (M. ulcerans), the causative agent of the devastating skin disease Buruli ulcer (BU), is characterized by an extremely low level of genetic diversity. Recently, we have reported the first discrimination of closely related M. ulcerans variants in the BU endemic Densu River Valley of Ghana. In the study real-time PCR-based single nucleotide polymorphism (SNP) typing at 89 predefined loci...
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