Article
Insertion sequence element single nucleotide polymorphism typing provides insights into the population structure and evolution of Mycobacterium ulcerans across Africa.
Applied and environmental microbiology - 1 Feb 2014
Vandelannoote Koen, Jordaens Kurt, Bomans Pieter, Leirs Herwig, Durnez Lies, Affolabi Dissou, Sopoh Ghislain, Aguiar Julia, Phanzu Delphin Mavinga, Kibadi Kapay, Eyangoh Sara, Manou Louis Bayonne, Phillips Richard Odame, Adjei Ohene, Ablordey Anthony, Rigouts Leen, Portaels Françoise, Eddyani Miriam, de Jong Bouke C
Abstract excerpt
Buruli ulcer is an indolent, slowly progressing necrotizing disease of the skin caused by infection with Mycobacterium ulcerans. In the present study, we applied a redesigned technique to a vast panel of M. ulcerans disease isolates and clinical samples originating from multiple African disease foci in order to (i) gain fundamental insights into the population structure and evolutionary history of the pathogen...
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