Article
Single nucleotide polymorphisms on the road to strain differentiation in Mycobacterium ulcerans.
Journal of clinical microbiology - 1 Nov 2009
Käser Michael, Hauser Julia, Pluschke Gerd
Abstract excerpt
The genomic fine-typing of strains of Mycobacterium ulcerans, the causative agent of the emerging human disease Buruli ulcer, is difficult due to the clonal population structure of geographical lineages. Although large sequence polymorphisms (LSPs) resulted in the clustering of patient isolates originating from across the globe, differentiation of strains within continents using conventional typing methods is...
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