Article
Lamin b1 polymorphism influences morphology of the nuclear envelope, cell cycle progression, and risk of neural tube defects in mice.
PLoS genetics - 1 Jan 2012
De Castro Sandra C P, Malhas Ashraf, Leung Kit-Yi, Gustavsson Peter, Vaux David J, Copp Andrew J, Greene Nicholas D E
Abstract excerpt
Neural tube defects (NTDs), including spina bifida and anencephaly, are common birth defects whose complex multigenic causation has hampered efforts to delineate their molecular basis. The effect of putative modifier genes in determining NTD susceptibility may be investigated in mouse models, particularly those that display partial penetrance such as curly tail, a strain in which NTDs result from a hypomorphic...
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