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Article

Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail.

Nature genetics - 1 Jul 2001

Kibar Z, Vogan K J, Groulx N, Justice M J, Underhill D A, Gros P

Abstract excerpt

Neural tube defects (NTDs) such as spina bifida and anencephaly are common congenital malformations in humans (1/1,000 births) that result from failure of the neural tube to close during embryogenesis. The etiology of NTDs is complex, with both genetic and environmental contributions; the genetic component has been extensively studied with mouse models. Loop-tail (Lp) is a semidominant mutation on mouse...

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PMID: 11431695
DOI: 10.1038/90081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

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Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail.PMID 11431695Read ↗

Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification.Semantic proximity Read ↗

The loop-tail mouse model displays open and closed caudal neural tube defects.Semantic proximity Read ↗

Transcription mapping and expression analysis of candidate genes in the vicinity of the mouse Loop-tail mutation.Semantic proximity Read ↗

Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp).Semantic proximity Read ↗

Contribution of VANGL2 mutations to isolated neural tube defects.Semantic proximity Read ↗

Identification of the mouse Loop-tail gene: a model for human craniorachischisis?Semantic proximity Read ↗

A novel hypomorphic Looptail allele at the planar cell polarity Vangl2 gene.Semantic proximity Read ↗

Molecular and cellular mechanisms underlying neural tube defects in the loop-tail mutant mouse.Semantic proximity Read ↗

Genetic basis of neural tube defects: the mouse gene loop-tail maps to a region of chromosome 1 syntenic with human 1q21-q23.Semantic proximity Read ↗

Loop-tail phenotype in heterozygous mice and neural tube defects in homozygous mice result from a nonsense mutation in the Vangl2 gene.Semantic proximity Read ↗

An update to the list of mouse mutants with neural tube closure defects and advances toward a complete genetic perspective of neural tube closure.Semantic proximity Read ↗

Curly tail: a 50-year history of the mouse spina bifida model.Semantic proximity Read ↗

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