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Article

Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail.

Nature genetics - 1 Jul 2001

Kibar Z, Vogan K J, Groulx N, Justice M J, Underhill D A, Gros P

Abstract excerpt

Neural tube defects (NTDs) such as spina bifida and anencephaly are common congenital malformations in humans (1/1,000 births) that result from failure of the neural tube to close during embryogenesis. The etiology of NTDs is complex, with both genetic and environmental contributions; the genetic component has been extensively studied with mouse models. Loop-tail (Lp) is a semidominant mutation on mouse...

Topics

Amino Acid Sequence
Animals
Cloning, Molecular
DNA, Complementary
Drosophila
Drosophila Proteins
In Situ Hybridization
Membrane Proteins
Mice
Mice, Inbred Strains
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nerve Tissue Proteins

Neural Tube Defects

Sequence Homology, Amino Acid

Tissue Distribution

Source

Identifiers

PMID: 11431695
DOI: 10.1038/90081

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail.PMID 11431695Read ↗

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The loop-tail mouse model displays open and closed caudal neural tube defects.Semantic proximity Read ↗

Transcription mapping and expression analysis of candidate genes in the vicinity of the mouse Loop-tail mutation.Semantic proximity Read ↗

Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp).Semantic proximity Read ↗

Contribution of VANGL2 mutations to isolated neural tube defects.Semantic proximity Read ↗

Identification of the mouse Loop-tail gene: a model for human craniorachischisis?Semantic proximity Read ↗

A novel hypomorphic Looptail allele at the planar cell polarity Vangl2 gene.Semantic proximity Read ↗

Molecular and cellular mechanisms underlying neural tube defects in the loop-tail mutant mouse.Semantic proximity Read ↗

Genetic basis of neural tube defects: the mouse gene loop-tail maps to a region of chromosome 1 syntenic with human 1q21-q23.Semantic proximity Read ↗

Loop-tail phenotype in heterozygous mice and neural tube defects in homozygous mice result from a nonsense mutation in the Vangl2 gene.Semantic proximity Read ↗

An update to the list of mouse mutants with neural tube closure defects and advances toward a complete genetic perspective of neural tube closure.Semantic proximity Read ↗

Curly tail: a 50-year history of the mouse spina bifida model.Semantic proximity Read ↗

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